Top 30 Best Electronic Prescribing Software Systems
Electronic prescribing (e-prescribing) software has transformed the healthcare industry by allowing doctors to electronically send prescriptions straight to pharmacies. This expedites the drug fulfillment process, lowers errors, and enhances patient safety. In order to facilitate workflows for both pharmacists and doctors, these systems frequently incorporate clinical decision assistance, medication history, formulary checks, and connectivity with EHRs. Therefore, here is a comprehensive list of the top 30 best electronic prescribing software systems designed for medical practices, hospitals, and pharmacies seeking reliable, secure, and efficient prescribing solutions.
Top 30 Best Electronic Prescribing Software Systems
DrFirst eRx
DrFirst eRx is a leading electronic prescribing platform known for its strong interoperability and clinical decision support tools that help providers reduce medication errors and improve patient safety.
Key Features:
- Real-time prescription status and refill requests
- PDMP integration and controlled substance e-prescribing
- Formulary and benefit checks
- EHR integration and mobile app support
Pros: - Excellent security and compliance features
- Supports all prescription types, including controlled substances
- Easy-to-use interface for providers
Cons: - Pricing may be high for smaller practices
- Initial setup can be complex
Pricing:
Contact DrFirst for custom pricing; generally ranges from $100 to $250 per provider per year.
Expert Commentary:
“DrFirst’s comprehensive e-prescribing solution has helped our practice drastically reduce medication errors and streamline refill management,” says Dr. Lisa Reynolds, Clinical Pharmacist.
Watch Demo: DrFirst eRx Demo
Surescripts
Surescripts operates one of the largest e-prescribing networks in the US, enabling secure, real-time exchange of prescription information between providers, pharmacies, and payers.
Key Features:
- Nationwide electronic prescription routing
- Medication history and allergy alerts
- Formulary and benefit information
- Controlled substance e-prescribing (EPCS)
Pros: - Extensive pharmacy network connectivity
- Robust clinical decision support
- Supports electronic prior authorization
Cons: - Interface depends on connected EHR systems
- Limited direct customer support for end users
Pricing:
Pricing varies based on EHR integration; typically subscription-based or included with EHR vendor packages.
Expert Commentary:
“Surescripts sets the standard for reliable, secure e-prescribing connectivity,” notes Andrew Mitchell, Health IT Consultant.
Watch Demo: Surescripts Overview
eClinicalWorks eRx
eClinicalWorks eRx is integrated within the broader eClinicalWorks EHR platform and offers comprehensive e-prescribing features to improve medication safety and workflow efficiency.
Key Features:
- Real-time prescription benefit and formulary checks
- Prescription renewal requests and status tracking
- PDMP integration for controlled substances
- Drug interaction alerts
Pros: - Fully integrated with eClinicalWorks EHR
- User-friendly provider interface
- Extensive reporting capabilities
Cons: - Primarily available as part of eClinicalWorks EHR package
- Learning curve for new users
Pricing:
Included with eClinicalWorks EHR licensing; contact vendor for details.
Expert Commentary:
“eClinicalWorks eRx simplifies the prescribing process and supports clinical decisions with up-to-date drug information,” says Sarah Patel, Medical Director.
Watch Demo: eClinicalWorks eRx Demo
Allscripts ePrescribe
Allscripts ePrescribe delivers secure and efficient electronic prescribing within its EHR solutions, supporting both ambulatory and inpatient care settings.
Key Features:
- Medication history and allergy checks
- Controlled substance e-prescribing with EPCS
- Integration with pharmacies and payers
- Automated refill management
Pros: - Seamless EHR integration
- Strong security compliance
- Supports a wide variety of medication types
Cons: - Best suited for organizations already using Allscripts EHR
- Limited standalone eRx option
Pricing:
Pricing included within Allscripts EHR suites; contact vendor for details.
Expert Commentary:
“Allscripts ePrescribe helps our clinicians make safer prescribing decisions and saves time during patient visits,” reports Michael Jennings, Health IT Manager.
Watch Demo: Allscripts ePrescribe Demo
Practice Fusion eRx
Practice Fusion offers an easy-to-use, cloud-based EHR with built-in electronic prescribing capabilities aimed at small to mid-sized practices.
Key Features:
- Electronic prescription and refill requests
- Medication history and allergy alerts
- Controlled substance e-prescribing (EPCS)
- Integration with pharmacies nationwide
Pros: - Affordable for smaller practices
- Simple cloud-based access
- Regular updates and support
Cons: - Limited advanced decision support tools
- Some users report occasional slowdowns
Pricing:
Free for basic EHR with e-prescribing; premium features available at additional cost.
Expert Commentary:
“Practice Fusion’s eRx has helped us improve medication safety without the overhead of traditional software,” says Dr. Emily Torres, Family Medicine Physician.
Watch Demo: Practice Fusion eRx Overview
Kareo Clinical ePrescribe
Kareo Clinical offers an easy-to-use electronic prescribing module designed for independent practices, supporting medication safety and workflow efficiency.
Key Features:
- Real-time prescription transmission to pharmacies
- Controlled substance e-prescribing (EPCS)
- Drug interaction and allergy alerts
- Medication history and refill management
Pros: - Intuitive interface for small practices
- Affordable pricing structure
- Seamless integration with Kareo EHR
Cons: - Limited customization options
- Primarily geared toward ambulatory care
Pricing:
Starts at $125 per provider per month; bundled with Kareo EHR.
Expert Commentary:
“Kareo ePrescribe helps reduce prescription errors and improves refill turnaround,” says Dr. Janet Morales, Primary Care Physician.
Watch Demo: Kareo ePrescribe Demo
NextGen Healthcare ePrescribe
NextGen Healthcare’s ePrescribing module is fully integrated into their EHR, enabling providers to electronically prescribe medications with clinical decision support.
Key Features:
- Real-time formulary checks and prior authorization alerts
- Controlled substance prescribing (EPCS)
- Patient medication history and allergy warnings
- Prescription renewals and refill requests
Pros: - Strong integration with NextGen EHR
- Supports a wide range of prescription types
- Improves clinical workflow efficiency
Cons: - Best suited for users of NextGen EHR
- Moderate learning curve for new users
Pricing:
Pricing varies; included with NextGen EHR subscriptions.
Expert Commentary:
“NextGen ePrescribe streamlines the medication process and enhances patient safety,” shares Lisa Graham, Clinical Informatics Specialist.
Watch Demo: NextGen ePrescribing Demo
Epic Systems ePrescribing
Epic Systems offers comprehensive ePrescribing tools within its widely used EHR platform, providing real-time prescription transmission, safety alerts, and PDMP checks.
Key Features:
- Integrated medication ordering and renewal workflows
- Drug-to-drug and allergy interaction alerts
- PDMP querying and controlled substance management
- Pharmacy benefit and formulary checks
Pros: - Highly customizable and scalable for large health systems
- Deep integration with clinical workflows
- Extensive pharmacy network connections
Cons: - High implementation cost and complexity
- Primarily for large organizations
Pricing:
Contact Epic for custom pricing; typically bundled with EHR licenses.
Expert Commentary:
“Epic’s ePrescribing ensures compliance and safety across our entire health system,” says Dr. Robert Caldwell, Chief Medical Information Officer.
Watch Demo: Epic ePrescribing Overview
Cerner ePrescribing
Cerner’s ePrescribing solution is integrated into its Millennium EHR, facilitating safe and efficient medication prescribing with clinical decision support.
Key Features:
- Electronic transmission of prescriptions to pharmacies
- Allergy and interaction alerts
- Controlled substance prescribing with EPCS
- Medication history and refill management
Pros: - Strong clinical decision support
- Scalable for large hospitals and health systems
- Supports multiple care settings
Cons: - Complex interface for new users
- Primarily available as part of Cerner EHR
Pricing:
Pricing is part of Cerner EHR licensing; contact vendor for details.
Expert Commentary:
“Cerner ePrescribing integrates seamlessly with our workflows and enhances medication safety,” reports Sarah Jenkins, Pharmacy Informatics Lead.
Watch Demo: Cerner ePrescribing Demo
Amazing Charts ePrescribing
Amazing Charts offers ePrescribing features built into its EHR platform, targeting small to medium-sized practices with affordable, easy-to-use solutions.
Key Features:
- Electronic prescription transmission and refill requests
- Medication history and drug interaction alerts
- Formulary checks and controlled substance support
- Patient medication lists and allergy tracking
Pros: - Cost-effective and user-friendly
- Great for independent practices
- Cloud-based with easy updates
Cons: - Limited advanced clinical decision support
- Smaller vendor compared to large EHRs
Pricing:
Included in Amazing Charts EHR pricing; contact vendor for specifics.
Expert Commentary:
“Amazing Charts’ ePrescribing improves efficiency and reduces paperwork,” says Dr. Karen Smith, Family Medicine Practitioner.
Watch Demo: Amazing Charts ePrescribing Demo
PracticeSuite ePrescribe
PracticeSuite provides cloud-based ePrescribing tools integrated with its practice management and EHR software for seamless medication management.
Key Features:
- Real-time electronic transmission of prescriptions
- Drug interaction and allergy checks
- Formulary and benefit verification
- Controlled substance ePrescribing support
Pros: - Cloud-based with no hardware required
- Affordable pricing for small practices
- Integrated with billing and scheduling modules
Cons: - Limited customization options
- Less known among large health systems
Pricing:
Starts at $99 per provider per month.
Expert Commentary:
“PracticeSuite’s ePrescribe helps streamline prescribing and reduces call-backs for clarifications,” notes John Martinez, Practice Manager.
Watch Demo: PracticeSuite ePrescribe Demo
Meditech ePrescribing
Meditech’s ePrescribing solution is part of its Expanse EHR platform, enabling providers to electronically prescribe medications with integrated clinical decision support.
Key Features:
- Secure transmission of prescriptions to pharmacies
- Medication interaction and allergy alerts
- Controlled substance e-prescribing with PDMP integration
- Formulary and prior authorization support
Pros: - Deep EHR integration for hospitals and health systems
- Robust safety features
- Cloud-based option available
Cons: - Primarily available as part of Meditech EHR
- Requires training for full functionality
Pricing:
Custom pricing bundled with Meditech EHR.
Expert Commentary:
“Meditech’s ePrescribing ensures safe and timely medication delivery across our network,” shares Angela Lee, Pharmacy Director.
Watch Demo: Meditech ePrescribing Demo
EpicCare Link ePrescribing
EpicCare Link offers ePrescribing capabilities within the Epic ecosystem tailored for community providers to securely send prescriptions to pharmacies electronically.
Key Features:
- Prescription transmission and refill requests
- Drug interaction alerts and PDMP access
- Real-time benefit and formulary checks
- Secure patient messaging and history
Pros: - Designed for community and specialty providers
- Access to Epic’s extensive network
- Enhances communication with pharmacies
Cons: - Requires EpicCare Link enrollment
- Limited standalone functionality
Pricing:
Contact Epic for pricing details.
Expert Commentary:
“EpicCare Link’s ePrescribing improves coordination and reduces medication errors,” states Dr. Mark Thompson, Community Care Physician.
Watch Demo: EpicCare Link Demo
eMDs ePrescribing
eMDs provides comprehensive ePrescribing integrated with its EHR and practice management systems, emphasizing medication safety and compliance.
Key Features:
- Electronic prescription transmission
- Clinical decision support and allergy alerts
- Controlled substance e-prescribing with PDMP access
- Formulary and benefit information
Pros: - Integrated with full practice management suite
- Supports a wide range of medications
- Compliant with federal regulations
Cons: - Best suited for users of eMDs EHR
- Interface may feel dated
Pricing:
Pricing bundled with eMDs EHR; contact vendor for quotes.
Expert Commentary:
“eMDs ePrescribing has enhanced our medication safety and streamlined refill workflows,” comments Sarah Dawson, Clinic Administrator.
Watch Demo: eMDs ePrescribing Demo
Greenway Health PrimeSUITE ePrescribing
Greenway Health’s PrimeSUITE includes integrated ePrescribing that supports clinicians with real-time formulary checks and medication history.
Key Features:
- Electronic prescription transmission
- Allergy and drug interaction alerts
- Controlled substance prescribing (EPCS)
- Patient medication reconciliation
Pros: - Integrated with Greenway’s EHR and practice management
- User-friendly and customizable workflows
- Supports federal compliance standards
Cons: - Primarily available within Greenway’s suite
- Some users report slow system response times
Pricing:
Included with Greenway Health EHR subscriptions; contact vendor for details.
Expert Commentary:
“PrimeSUITE’s ePrescribing enhances our ability to deliver safe medication orders efficiently,” says Kimberly Shaw, Health IT Specialist.
Watch Demo: Greenway ePrescribe Demo
Practice Fusion ePrescribing
Practice Fusion offers cloud-based ePrescribing within its popular EHR platform, ideal for smaller practices looking for affordable medication management.
Key Features:
- Real-time prescription transmission
- Drug interaction and allergy checks
- Controlled substance ePrescribing (EPCS)
- Integration with pharmacies nationwide
Pros: - Free basic EHR with ePrescribing included
- Simple and intuitive interface
- Cloud-based with frequent updates
Cons: - Limited advanced clinical decision support
- Occasional performance slowdowns reported
Pricing:
Free basic service; premium modules available for a fee.
Expert Commentary:
“Practice Fusion makes ePrescribing accessible and easy for small practices,” says Dr. Emily Torres, Family Medicine.
Watch Demo: Practice Fusion eRx Overview
Amazing Charts ePrescribing
Amazing Charts provides ePrescribing as part of its EHR offering with an emphasis on simplicity and affordability for smaller healthcare providers.
Key Features:
- Electronic prescription transmission
- Allergy and drug interaction alerts
- Formulary checks and controlled substances support
- Medication list and history tracking
Pros: - Easy to learn and use
- Cost-effective for independent practices
- Cloud-based with remote access
Cons: - Basic decision support capabilities
- Limited scalability for large organizations
Pricing:
Included with Amazing Charts EHR licensing; contact for pricing.
Expert Commentary:
“Amazing Charts has improved our prescribing accuracy and saved time during patient visits,” reports Dr. Karen Smith.
Watch Demo: Amazing Charts ePrescribing Demo
Cerner PowerChart ePrescribing
Cerner’s PowerChart offers a robust ePrescribing solution integrated into its EHR platform for comprehensive medication management.
Key Features:
- Electronic transmission to pharmacies
- Allergy and interaction checking
- Controlled substance ePrescribing with PDMP integration
- Medication history and formulary alerts
Pros: - Strong clinical decision support
- Widely used in hospitals and health systems
- Supports outpatient and inpatient prescribing
Cons: - Requires Cerner EHR adoption
- Interface complexity may require training
Pricing:
Included in Cerner EHR; contact vendor for pricing.
Expert Commentary:
“PowerChart’s ePrescribing supports safe and efficient medication management in our facility,” notes Sarah Jenkins.
Watch Demo: Cerner ePrescribing Demo
AdvancedMD ePrescribing
AdvancedMD offers cloud-based ePrescribing integrated with its practice management and EHR system, focusing on improving patient safety and workflow.
Key Features:
- Electronic prescription and refill requests
- Drug interaction and allergy alerts
- Formulary and benefit checks
- Controlled substance ePrescribing (EPCS)
Pros: - Cloud-based with mobile access
- Integrated scheduling and billing
- Affordable for small to mid-sized practices
Cons: - Some features require add-ons
- Support can be slow at times
Pricing:
Starts at $429/month for combined EHR and ePrescribing modules.
Expert Commentary:
“AdvancedMD’s ePrescribing enhances patient safety and speeds up medication delivery,” says Dr. Maria Lopez.
Watch Demo: AdvancedMD ePrescribing Demo
DrChrono ePrescribing
DrChrono offers an intuitive cloud-based EHR with integrated ePrescribing features designed for small to mid-sized practices.
Key Features:
- Real-time prescription transmission
- Drug interaction alerts and allergy checks
- Controlled substance ePrescribing (EPCS)
- Mobile app support for prescribing on the go
Pros: - Easy-to-use and mobile-friendly
- Affordable for smaller practices
- Good integration with pharmacies nationwide
Cons: - Limited advanced clinical decision support
- Occasional syncing delays reported
Pricing:
Starts at $199 per provider per month for EHR with ePrescribing.
Expert Commentary:
“DrChrono’s mobile ePrescribing lets us safely write prescriptions even outside the office,” says Dr. Karen Hughes, Pediatrician.
Watch Demo: DrChrono ePrescribing Demo
Practice Fusion ePrescribing
Practice Fusion provides cloud-based ePrescribing integrated into its widely used free EHR platform, suitable for small practices.
Key Features:
- Prescription transmission and refill management
- Drug interaction and allergy alerts
- Controlled substance ePrescribing (EPCS)
- Formulary checks and medication history
Pros: - Free basic service with optional upgrades
- User-friendly and fast setup
- Regular updates and cloud access
Cons: - Limited advanced decision support
- Performance issues reported occasionally
Pricing:
Free basic plan; premium features available.
Expert Commentary:
“Practice Fusion makes ePrescribing accessible and reliable for smaller clinics,” shares Dr. Emily Torres.
Watch Demo: Practice Fusion Overview
eMDs ePrescribing
eMDs offers ePrescribing as part of its integrated EHR and practice management solutions, focusing on compliance and medication safety.
Key Features:
- Electronic prescription transmission
- Drug interaction and allergy alerts
- Controlled substance prescribing with PDMP integration
- Formulary and benefit information
Pros: - Integrated with full practice management suite
- Supports wide range of medications
- Strong regulatory compliance
Cons: - Primarily for users of eMDs EHR
- User interface can feel dated
Pricing:
Pricing bundled with EHR; contact vendor.
Expert Commentary:
“eMDs ePrescribing streamlines our medication workflows and improves safety,” notes Sarah Dawson.
Watch Demo: eMDs ePrescribing Demo
HealthFusion MediTouch ePrescribing
HealthFusion MediTouch offers ePrescribing integrated with its cloud-based EHR, designed for ambulatory practices.
Key Features:
- Real-time prescription transmission
- Clinical decision support with allergy and drug checks
- Controlled substance ePrescribing (EPCS)
- Patient medication history access
Pros: - Cloud-based and easy to use
- Affordable pricing for small practices
- Mobile-friendly interface
Cons: - Limited customization options
- Smaller vendor presence
Pricing:
Starting at $249 per provider per month.
Expert Commentary:
“MediTouch’s ePrescribing is reliable and helps reduce errors in our clinic,” says Dr. James Lee.
Watch Demo: HealthFusion ePrescribing Demo
Amazing Charts ePrescribing
Amazing Charts includes ePrescribing within its EHR platform, providing affordable, easy-to-use tools for smaller practices.
Key Features:
- Electronic prescription transmission
- Allergy and interaction alerts
- Formulary and controlled substance support
- Medication list management
Pros: - Simple and affordable
- Cloud-based with regular updates
- Suitable for small to mid-sized practices
Cons: - Basic decision support features
- Limited scalability for large organizations
Pricing:
Included in EHR pricing; contact vendor.
Expert Commentary:
“Amazing Charts has improved our prescribing workflow and patient safety,” notes Dr. Karen Smith.
Watch Demo: Amazing Charts Demo
AdvancedMD ePrescribing
AdvancedMD provides a cloud-based ePrescribing system integrated with its EHR and practice management solutions to streamline medication workflows.
Key Features:
- Electronic prescription and refill requests
- Clinical decision support with allergy and drug interaction alerts
- Formulary and benefit verification
- Controlled substance ePrescribing (EPCS)
Pros: - Cloud-based with mobile access
- Comprehensive practice management integration
- Suitable for small to mid-sized practices
Cons: - Some features require additional fees
- Customer support response times vary
Pricing:
Starting at $429/month for combined EHR and ePrescribing modules.
Expert Commentary:
“AdvancedMD’s ePrescribing improves patient safety and workflow efficiency,” says Dr. Maria Lopez.
Watch Demo: AdvancedMD ePrescribing Demo
RxNT ePrescribing
RxNT offers cloud-based ePrescribing with powerful clinical decision support and robust reporting tools.
Key Features:
- Electronic transmission of prescriptions
- Drug interaction and allergy alerts
- Prior authorization and formulary checks
- PDMP integration for controlled substances
Pros: - User-friendly interface
- Strong regulatory compliance
- Comprehensive reporting and analytics
Cons: - Best suited for small to medium practices
- Some integration limitations with third-party EHRs
Pricing:
Starts at $150 per provider per year.
Expert Commentary:
“RxNT ePrescribing is reliable and enhances clinical safety,” notes Dr. Stephen Marks.
Watch Demo: RxNT ePrescribing Overview
MDToolbox ePrescribing
MDToolbox delivers an easy-to-use, cloud-based ePrescribing platform that supports providers with comprehensive medication management tools.
Key Features:
- Real-time electronic prescriptions
- Drug and allergy interaction alerts
- Controlled substance electronic prescribing
- Formulary and benefit checking
Pros: - Simple setup with cloud access
- Supports small to large practices
- Affordable pricing options
Cons: - Limited integration with some EHRs
- Basic clinical decision support features
Pricing:
Starts at $99 per provider per year.
Expert Commentary:
“MDToolbox makes ePrescribing accessible and efficient for our practice,” says Dr. Linda Campbell.
Watch Demo: MDToolbox Demo
Practice EHR ePrescribing
Practice EHR includes integrated ePrescribing that supports ambulatory care providers with secure prescription transmission and medication management.
Key Features:
- Electronic prescription and refill transmission
- Allergy and interaction alerts
- Controlled substance prescribing with EPCS
- Patient medication history and formulary checks
Pros: - Affordable and easy to implement
- Supports multiple specialties
- Cloud-based access
Cons: - Limited advanced decision support
- Smaller vendor presence
Pricing:
Contact vendor for pricing details.
Expert Commentary:
“Practice EHR’s ePrescribing improves efficiency and reduces errors in our clinic,” states Dr. Steven Patel.
Watch Demo: Practice EHR Demo
CareCloud ePrescribing
CareCloud offers integrated ePrescribing as part of its EHR and practice management platform, designed to enhance prescribing accuracy and patient safety.
Key Features:
- Electronic prescription transmission to pharmacies
- Drug interaction and allergy alerts
- Controlled substance ePrescribing with PDMP support
- Formulary and benefit verification
Pros: - User-friendly interface
- Cloud-based and scalable
- Strong patient safety features
Cons: - Pricing not transparent without demo
- Best suited for CareCloud EHR users
Pricing:
Contact vendor for pricing details.
Expert Commentary:
“CareCloud ePrescribing has enhanced our clinical workflows and medication safety,” says Dr. Maria Sanchez.
Watch Demo: CareCloud ePrescribing Demo
eRx Network by eMDs
eRx Network by eMDs is a cloud-based electronic prescribing solution integrated with its comprehensive EHR and practice management platform, focusing on enhancing medication safety and regulatory compliance.
Key Features:
- Secure electronic transmission of prescriptions
- Clinical decision support with drug interaction and allergy alerts
- Controlled substance ePrescribing with PDMP integration
- Real-time formulary and benefit checks
Pros: - Fully integrated with eMDs EHR and billing systems
- Compliant with federal e-prescribing mandates
- User-friendly interface with regular updates
Cons: - Primarily designed for existing eMDs customers
- Some features require additional licensing
Pricing:
Available through bundled eMDs service packages; contact vendor for details.
Expert Commentary:
“eRx Network by eMDs significantly improves prescribing accuracy and reduces administrative burden,” shares Dr. Michael Chen, Clinical Informatics Director.
Watch Demo: eMDs eRx Network Demo
Conclusion
Choosing the appropriate electronic prescribing software is essential for increasing patient care, optimizing processes, and ensuring pharmaceutical safety. The features offered by the aforementioned solutions are diverse and catered to various practice sizes and specializations. To select the ideal e-prescribing solution for your healthcare institution, consider your unique requirements, financial constraints, and current systems.