Top 30 Best Healthcare API Solutions for Custom Integrations

1. FHIR (Fast Healthcare Interoperability Resources)

Brief Description: Developed by HL7, FHIR is the leading healthcare interoperability standard built on modern web protocols like REST and JSON, enabling easy data exchange across EHRs and digital health apps.
Key Features: RESTful APIs, modular resources, JSON/XML formats, and broad EHR support.
Pros: Widely adopted, open source, developer friendly.
Cons: Can be complex to implement without technical expertise.
Pricing: Free to use, with costs arising only from custom development.
Expert Insight: “FHIR is the backbone of modern healthcare integration—essential for any scalable system.” — Dr. Emily Carr
Demo: See how FHIR works in real-world integrations

2. Redox

Brief Description: Redox is a leading healthcare integration platform offering unified APIs to connect apps with over 2,000 healthcare organizations.
Key Features: EHR connectivity, data normalization, HL7/FHIR support, real-time syncing.
Pros: Scalable, vendor-agnostic, strong security features.
Cons: Requires subscription for full features.
Pricing: Custom pricing based on volume and scope.
Expert Insight: “Redox simplifies complex integrations with one API layer across systems.” — Morgan Blake, Health IT Lead
Demo: Watch Redox in action

3. Health Gorilla

Brief Description: Health Gorilla offers a clinical data API platform enabling secure access to complete patient records from national networks.
Key Features: Record retrieval, diagnostics ordering, FHIR support, and data exchange.
Pros: Nationwide data access, HIPAA-compliant, easy EHR integration.
Cons: Limited access without partnership approval.
Pricing: Custom quotes depending on usage.
Expert Insight: “Health Gorilla bridges the gap between fragmented patient data and real-time care.” — Sarah K., Clinical Data Analyst
Demo: Explore Health Gorilla’s API platform

4. Validic

Brief Description: Validic provides an API platform to access real-time health data from wearables, remote monitoring devices, and fitness apps.
Key Features: Device data aggregation, wellness tracking, and RPM support.
Pros: Strong IoT support, real-time updates, scalable architecture.
Cons: Premium pricing for advanced features.
Pricing: Custom quotes based on usage.
Expert Insight: “Validic leads in connecting remote patient monitoring systems and wearables to electronic health records.” — Joe Douglas, Digital Health Expert
Demo: See how Validic integrates health data

5. Human API

Brief Description: Human API offers an aggregation platform for health data from various sources, including fitness devices, wearables, and EHRs, giving patients and healthcare providers real-time access to critical health information.
Key Features: Data aggregation, real-time access to health records, integration with wearables and fitness trackers.
Pros: User-friendly, extensive third-party app compatibility, patient-centered.
Cons: Limited coverage outside the US, requires patient consent for data sharing.
Pricing: Custom pricing based on the volume of data and integrations.
Expert Insight: “Human API empowers patients to own their health data while enhancing provider capabilities.” — Laura T., Health Tech Analyst
Demo: Watch Human API in action

6. Cerner Open Developer Experience (Code)

Brief Description: Cerner’s open platform allows developers to build custom solutions and integrate healthcare applications with Cerner’s EHR system using their APIs.
Key Features: REST APIs, FHIR support, seamless integration with Cerner’s EHR systems, and robust developer tools.
Pros: Established in the healthcare market, rich documentation, robust community.
Cons: Focused on Cerner’s ecosystem; may not be as versatile for non-Cerner systems.
Pricing: Free with custom pricing for premium features and services.
Expert Insight: “Cerner’s API platform is the gateway for integrating custom healthcare apps with one of the most widely used EHR systems globally.” — Dr. Mike J., EHR Integration Specialist
Demo: Explore Cerner’s developer tools

7. Allscripts Developer Program

Brief Description: Allscripts offers a set of open APIs to connect third-party applications with their EHR, making healthcare data more accessible and interoperable.
Key Features: EHR integration, FHIR support, secure APIs, data-driven insights.
Pros: Scalable, offers both cloud-based and on-premise options, strong security features.
Cons: Primarily geared toward large healthcare systems, implementation can be complex.
Pricing: Free access to basic APIs; pricing for premium services varies.
Expert Insight: “Allscripts makes it easier for developers to create customized healthcare applications with strong support and flexibility.” — Jake R., Senior Health IT Developer
Demo: Watch Allscripts integration demo

8. Microsoft Azure Healthcare API

Brief Description: Microsoft’s Azure Healthcare API provides an integrated platform to access healthcare data using FHIR standards, allowing for seamless interoperability between systems.
Key Features: Real-time data access, FHIR-based API, secure data transfer, and machine learning integration.
Pros: Scalable, secure, backed by Microsoft’s cloud infrastructure.
Cons: More suitable for large organizations due to the infrastructure setup.
Pricing: Pay-as-you-go based on data usage and processing.
Expert Insight: “Azure Healthcare API enables healthcare organizations to unlock the power of cloud computing for real-time health data analytics.” — David L., Cloud Solutions Architect
Demo: See how Azure Healthcare API works

9. MedeAnalytics

Brief Description: MedeAnalytics offers a healthcare data analytics API that integrates with EHRs to provide actionable insights through business intelligence tools and visualizations.
Key Features: Data analytics, predictive analytics, customizable dashboards, and EHR integration.
Pros: Strong analytics capabilities, scalable, comprehensive insights.
Cons: High learning curve for new users, tailored more for large healthcare systems.
Pricing: Custom pricing based on data volume and feature set.
Expert Insight: “MedeAnalytics transforms complex healthcare data into actionable insights that improve clinical and operational decision-making.” — Anna M., Healthcare Data

10. Palo Alto Networks Healthcare API

Brief Description: Palo Alto Networks offers robust security APIs for healthcare systems, helping organizations protect sensitive data and maintain compliance with HIPAA and other regulations.
Key Features: Data protection, security protocols, compliance support, threat intelligence integration.
Pros: Strong security focus, real-time threat detection, highly customizable.
Cons: More focused on cybersecurity than traditional health data integrations.
Pricing: Custom pricing based on the level of security services and integrations required.
Expert Insight: “As healthcare becomes a bigger target for cyberattacks, Palo Alto Networks is critical for protecting patient and system data.” — Greg W., Security Analyst
Demo: Watch Palo Alto Networks healthcare security demo

11. Smartcare API

Brief Description: Smartcare offers a cloud-based healthcare management system with an API designed to streamline patient care, billing, and scheduling, particularly for long-term care facilities.
Key Features: Patient management, billing automation, real-time scheduling, HIPAA compliance.
Pros: Focused on long-term care facilities, real-time data access, and secure patient information.
Cons: Limited features outside long-term care facilities, can be complex to set up.
Pricing: Custom pricing based on the size of the organization.
Expert Insight: “Smartcare’s solution is ideal for senior living and long-term care facilities needing streamlined patient management.” — Kelly H., Healthcare Consultant
Demo: Watch Smartcare API in action

12. Athenahealth API

Brief Description: Athenahealth provides a comprehensive healthcare API that integrates EHRs, practice management, and patient engagement into a single platform.
Key Features: Cloud-based EHR, billing services, patient scheduling, and care coordination.
Pros: Highly integrated, cloud-based, robust reporting and analytics.
Cons: Can be costly for smaller practices, setup might be complex for some users.
Pricing: Subscription-based with custom pricing depending on practice size.
Expert Insight: “Athenahealth’s API offers seamless integration, but practices need to be ready for the upfront costs.” — Mark L., Practice Manager
Demo: Explore Athenahealth’s API features

13. Tata Consultancy Services (TCS) Healthcare API

Brief Description: TCS offers an API platform for the healthcare sector that focuses on automation, patient data integration, and analytics, designed for large hospitals and healthcare organizations.
Key Features: EHR integration, patient care automation, predictive analytics, cloud-based platform.
Pros: Extensive industry experience, scalability, cloud infrastructure.
Cons: Primarily geared toward large-scale healthcare organizations, integration may be complex.
Pricing: Custom pricing based on the healthcare organization’s needs.
Expert Insight: “TCS provides enterprise-grade solutions, ideal for large healthcare organizations looking to scale.” — Emma R., Senior Consultant
Demo: Watch TCS Healthcare API demo

14. Health Samurai

Brief Description: Health Samurai offers a set of APIs and healthcare solutions for FHIR-based integration, supporting hospitals, health systems, and health app developers.
Key Features: FHIR-based APIs, patient record management, real-time data access.
Pros: Flexible, developer-friendly, open-source tools available.
Cons: Requires technical expertise for setup and integration.
Pricing: Free for basic use; custom pricing for enterprise solutions.
Expert Insight: “Health Samurai is a robust open-source platform that excels in interoperability, especially for healthcare startups.” — Jonathan M., Health IT Developer
Demo: Watch Health Samurai in action

15. NextGen Healthcare API

Brief Description: NextGen Healthcare provides a powerful API for managing patient care, EHRs, and practice management, with a focus on delivering efficient patient care in real-time.
Key Features: EHR integration, telemedicine support, real-time clinical data access.
Pros: Comprehensive suite of tools, great for integrated care systems, user-friendly interface.
Cons: Customizations may require additional development; pricing can be high for small practices.
Pricing: Custom pricing based on system size and usage.
Expert Insight: “NextGen offers an all-in-one solution, ideal for integrated healthcare systems with varying levels of complexity.” — Sarah W., Healthcare IT Consultant
Demo: Explore NextGen Healthcare API

16. Clarity Health API

Brief Description: Clarity Health provides an API platform designed to connect healthcare providers and patients, focusing on improving patient experience through data integration.
Key Features: Patient scheduling, clinical data exchange, and billing management.
Pros: Focused on improving patient experience, HIPAA-compliant, real-time data synchronization.
Cons: Primarily focused on scheduling and basic patient management.
Pricing: Subscription-based, with pricing depending on organization size and usage.
Expert Insight: “Clarity Health’s intuitive platform makes patient engagement simpler and more effective.” — Naomi R., Patient Engagement Specialist
Demo: Watch Clarity Health API in action

17. Zebra Medical Vision API

Brief Description: Zebra Medical Vision specializes in medical imaging analysis, offering APIs to help radiologists and healthcare providers gain better insights into medical images.
Key Features: AI-based medical imaging, image interpretation, radiology data integration.
Pros: Advanced AI capabilities, quick results for medical images.
Cons: Limited to imaging data, may not suit non-imaging-related applications.
Pricing: Custom pricing for enterprise solutions.
Expert Insight: “Zebra’s AI-powered imaging solutions are revolutionizing how healthcare providers interpret medical scans.” — Dr. Jake B., Radiologist
Demo: Watch Zebra Medical Vision in action

18. TruBridge API

Brief Description: TruBridge offers an API platform focused on optimizing revenue cycle management (RCM) and claims management in healthcare systems.
Key Features: Claims management, billing automation, RCM integration.
Pros: Cost-effective, easy integration with existing systems, HIPAA-compliant.
Cons: Primarily focused on billing; less comprehensive in other areas of healthcare integration.
Pricing: Based on subscription and claim volume.
Expert Insight: “TruBridge simplifies the claims process, improving the revenue cycle for healthcare organizations.” — Kevin J., RCM Expert
Demo: See TruBridge API in action

19. OmniSYS API

Brief Description: OmniSYS provides an API platform that focuses on automating claims processing, eligibility verification, and improving workflows in healthcare organizations.
Key Features: Claims processing, eligibility verification, workflow automation.
Pros: Streamlines administrative tasks, HIPAA-compliant, quick integration.
Cons: Focused more on administrative functions, may not suit clinical data needs.
Pricing: Custom pricing based on features and integrations.
Expert Insight: “OmniSYS brings efficiency to administrative processes, helping healthcare organizations reduce overhead.” — Rachel T., Healthcare Operations Manager
Demo: See OmniSYS API in action

20. Redox API

Brief Description: Redox offers a comprehensive API for integrating healthcare systems, providing a seamless data exchange between hospitals, clinics, and software providers.
Key Features: EHR integration, patient data sharing, interoperability solutions.
Pros: Excellent for interoperability, scalable, supports numerous healthcare standards.
Cons: Some configurations may be complex, and advanced setup requires technical expertise.
Pricing: Custom pricing depending on the scale and features needed.
Expert Insight: “Redox excels in making healthcare data exchange more seamless across disparate systems.” — Sandra K., IT Integration Specialist
Demo: Watch Redox API integration demo

21. Change Healthcare API

Brief Description: Change Healthcare offers an API platform focused on healthcare data exchange, claims processing, and interoperability solutions for healthcare organizations.
Key Features: EHR integration, payer-provider communication, revenue cycle management, and claims management.
Pros: Robust interoperability solutions, wide adoption in the healthcare sector, cloud-based.
Cons: Implementation might be complex for smaller organizations, and pricing is on the higher end.
Pricing: Custom pricing based on usage, features, and organization size.
Expert Insight: “Change Healthcare provides a comprehensive API solution that improves the flow of information across the entire healthcare ecosystem.” — Lisa D., Healthcare IT Strategist
Demo: Watch Change Healthcare API demo

22. Cerner API

Brief Description: Cerner offers a range of APIs that help healthcare organizations integrate EHR systems, improve clinical workflows, and streamline data management.
Key Features: EHR integration, clinical data sharing, patient engagement, telemedicine support.
Pros: Strong presence in healthcare EHR solutions, cloud-based infrastructure, HIPAA-compliant.
Cons: Complex configuration, higher costs for smaller organizations.
Pricing: Custom pricing based on the healthcare provider’s needs and usage.
Expert Insight: “Cerner’s API helps healthcare providers offer more streamlined care with access to critical patient data at the point of care.” — Dr. Jacob S., Health IT Consultant
Demo: Explore Cerner’s API capabilities

23. FHIRbase API

Brief Description: FHIRbase is an open-source API platform based on the FHIR standard, designed to support data integration for healthcare applications.
Key Features: FHIR support, data storage, open-source integration tools.
Pros: Free and open-source, fully FHIR-compliant, developer-friendly.
Cons: Requires technical expertise to implement and maintain; not a fully managed service.
Pricing: Free (open source) with optional paid support services.
Expert Insight: “FHIRbase allows developers to easily build FHIR-based integrations, but it’s best suited for those with a strong technical background.” — Mark P., Health IT Developer
Demo: Watch the FHIRbase integration tutorial

24. Surescripts API

Brief Description: Surescripts is an API that facilitates electronic prescribing, medication history, and health information exchange across various healthcare platforms.
Key Features: Electronic prescribing, medication history, secure data exchange, pharmacy integration.
Pros: Improves patient safety, streamlines prescriptions, connects multiple healthcare systems.
Cons: Primarily focused on medication-related workflows, may not address other healthcare needs.
Pricing: Custom pricing based on usage and integrations.
Expert Insight: “Surescripts simplifies the prescription process and ensures accurate medication information across different systems.” — Peter L., Clinical Pharmacist
Demo: Watch Surescripts API demonstration

25. Allscripts API

Brief Description: Allscripts provides a comprehensive API suite for healthcare organizations, focusing on EHR integration, practice management, and patient engagement tools.
Key Features: EHR solutions, patient scheduling, revenue cycle management, and data analytics.
Pros: Highly customizable, supports various healthcare workflows, robust analytics tools.
Cons: Can be complex to implement, higher cost for small practices.
Pricing: Custom pricing based on practice size and feature requirements.
Expert Insight: “Allscripts offers a flexible and comprehensive platform for integrating patient data across various healthcare settings.” — Emma T., EHR Specialist
Demo: Explore Allscripts API capabilities

26. CareSmartz360 API

Brief Description: CareSmartz360 offers an API for home care agencies to manage scheduling, billing, and client data efficiently.
Key Features: Home care management, patient scheduling, billing, and payroll automation.
Pros: Tailored to home care services, HIPAA-compliant, easy integration with third-party apps.
Cons: Limited features outside home care services, may not suit larger healthcare organizations.
Pricing: Custom pricing based on agency size and feature set.
Expert Insight: “CareSmartz360 is great for home care agencies looking for an all-in-one solution for managing their operations and patient data.” — Victoria J., Home Care Administrator
Demo: Watch CareSmartz360 API demo

28. Ribbon Health

Ribbon Health provides a comprehensive healthcare API solution that supports accurate provider data, insurance networks, and cost transparency. It enables healthcare developers to build smarter navigation and decision-support tools through real-time data aggregation and validation. Its API is widely used for improving referral management, patient access, and network design.

Key Features:

Real-time provider directory and insurance data
Claims-based quality and cost transparency
Robust FHIR-compatible APIs
Provider search, validation, and network optimization

Pros:

Highly accurate and scalable data infrastructure
Easy API integration with strong developer support
Improves care navigation and user experience

Cons:

May require enterprise-level customization for optimal use

Demo Video: Ribbon Health Overview – YouTube

29. Zus Health

Zus Health is a developer-first healthcare data platform that aggregates and standardizes patient records from EHRs, labs, and HIEs. Its FHIR-native APIs help healthcare organizations access longitudinal patient data, enabling faster and more informed care delivery. Zus is ideal for digital health companies seeking quick, reliable integrations.

Key Features:

Unified patient data from multiple sources
FHIR-based APIs for seamless integration
Consent and identity management tools
Developer sandbox and SDK support

Pros:

Streamlines healthcare data access and exchange
Fast integration and developer-friendly documentation
Designed specifically for modern health tech startups

Cons:

Still expanding coverage with some networks and sources

Demo Video: Zus Health Overview – YouTube

30. Healthie API

Healthie API offers a robust and flexible solution for organizations in wellness, nutrition, and allied health to embed telehealth, charting, scheduling, and client management into their apps. Its white-labeled infrastructure supports HIPAA compliance and is ideal for care delivery platforms looking for scalability and customizability.

Key Features:

Embedded telehealth and client communication tools
EHR, charting, scheduling, and billing functionality
HIPAA-compliant and customizable portals
Fully documented open API access

Pros:

Excellent for wellness and preventive health services
Fast go-to-market with a strong backend
Scales from solo practices to large organizations

Cons:

More suitable for non-acute care environments

Demo Video: Healthie Platform Demo – YouTube

30. 1upHealth API

Brief Description: 1upHealth provides an API platform that focuses on integrating electronic health records (EHR) data with applications, facilitating patient data access and interoperability.
Key Features: FHIR-based API, patient data access, healthcare app integration.
Pros: HIPAA-compliant, developer-friendly, great for building healthcare applications.
Cons: Primarily focused on EHR data, may not be suited for non-clinical use cases.
Pricing: Custom pricing based on features and integration needs.
Expert Insight: “1upHealth allows healthcare organizations to provide more access and control to patients over their health data.” — Alex L., Health App Developer
Demo: Watch 1upHealth API in action

Conclusion

In conclusion, each of these Top 30 Best Healthcare API Solutions for Custom Integrations offers a unique solution tailored to different aspects of healthcare integration, from patient management to billing and clinical data sharing. For organizations and developers, choosing the right API depends on specific needs, such as scalability, compliance, or integration with existing systems.

Top 30 Best Healthcare API Solutions for Custom Integrations