Top 30 Best Electronic Prescribing Software Systems

When it comes to patient care, there’s no room for mistakes. Medication errors, delays in filling prescriptions, and messy handwriting used to be common issues in healthcare. Electronic prescribing software has significantly changed how prescriptions are handled. Instead of relying on paper or fax, healthcare professionals can now send prescriptions directly to the pharmacy of the patient’s choice. This shift not only cuts down on errors but also supports better medication adherence and improved treatment outcomes.

Still, picking the right electronic prescribing software tool can be a challenge. With so many options on the market, it’s easy to feel lost. To make the decision easier, we’ve compiled a list of the Top 30 Best Electronic Prescribing Software Systems. From solo practices to large medical centers, this guide highlights trusted solutions that combine usability, security, and dependability to support different  clinical environments.

Top 30 Best Electronic Prescribing Software Systems

1. Tebra

Tebra’s e-prescribing software helps doctors send prescriptions directly to pharmacies, reducing paperwork and cutting down on prescription errors. As a result, patients are more likely to stick to their medication plans, and overall safety improves. The software works hand-in-hand with EHR and practice management tools, making prescription handling quicker and more precise. Doctors can view a patient’s medication history, receive alerts about possible drug interactions, and renew prescriptions without hassle. Insurance details are checked during the process, so patients are more likely to get the right medication without unnecessary delays.

Pros

• Easy to navigate, even for first-time users
• Helpful training materials for onboarding and ongoing use
• Integrates well with other tools to support practice operations

Cons

• Customer support via phone tends to be slow and frustrating
• Technical issues may take longer than expected to get resolved
• Contract management can feel overly complicated and unclear

2. NextGen Office

NextGen Office is a cloud-based EHR and practice management system built for small to mid-sized healthcare practices. It combines key functions such as e-prescribing, billing, scheduling, and clinical documentation in a single platform that works across desktop and mobile devices.

The AI Ambient Assist feature captures conversations between patients and providers, turning them into structured SOAP notes. This helps clinicians cut down on time spent on documentation. Users can also access features like a patient portal, lab system connections, and flexible workflows, all of which support smoother daily operations and more focused patient care.

Pros

• Easy-to-navigate interface
• Simplifies appointment booking and management

Cons

• Noticeably slow performance at times
• Customer support may not resolve issues promptly
• Requires too many clicks to complete tasks

3. TherapyNotes

TherapyNotes includes an e-prescribing feature that allows mental health and behavioral health professionals to send prescriptions electronically from within the platform. The tool includes built-in safety checks for potential drug interactions and known allergies. It also offers access to a patient’s medication history and formulary details, helping clinicians make more informed decisions during the prescription process.

Pros

• Quick and helpful customer support
• Offers different support options
• Known for excellent service and user assistance

Cons

• Some users experience delays in resolving technical issues
• Navigating the insurance billing process can be complicated

4. WebPT

WebPT’s electronic prescribing software focuses on the needs of physical therapy and rehabilitation clinics. It allows therapists to electronically manage prescriptions, request refills, and connect with patient records, helping reduce paperwork and manual errors. The system also handles prior authorizations electronically and sends alerts for medication issues, which can speed up and improve the accuracy of prescriptions.

Pros

• Built with rehab therapists in mind, offering features suited to their workflow
• Complies with HIPAA regulations to keep patient information secure

Cons

• Support response times may be delayed
• Costs more than some alternative options

5.  FollowMyHealth

FollowMyHealth is a cloud-based platform that helps patients stay connected with their healthcare providers. It brings several functions into one place, allowing users to manage appointments, view medical records, and request prescription refills through a single portal. The platform works well with various electronic health record (EHR) systems, keeping information current for both patients and care teams. Its clean interface and device compatibility make it a practical option for clinics of all sizes.

Pros

• Integrates smoothly with many widely used EHR systems
• Keeps medical records and prescriptions regularly updated
• Offers secure messaging for patient-provider communication

Cons

• Some users may experience delays when viewing test results or appointment notes

6. DrChrono

DrChrono’s electronic prescribing (eRx) system works directly within its cloud-based EHR, allowing healthcare professionals to send prescriptions straight to pharmacies. It supports both controlled and non-controlled medications and aligns with DEA and Surescripts regulations. Doctors can review a patient’s complete prescription history, check for drug interactions, set up preferred pharmacies, and handle prior authorizations electronically. All of this is available through iOS devices or web browsers, which makes the process quicker and more convenient for busy providers.

Pros

• Accessible on iOS with a user-friendly interface
• Cloud access makes it usable from any location
• Smooth integration with Apple Health

Cons

• The free plan offers only basic functionality
• Upgrading to a paid plan is necessary for full access to features

7. MDToolbox 

MDToolbox focuses on providing straightforward e-prescribing tools, making it a smart choice for small practices and specialists who prioritize medication management but don’t need a full EHR system. This platform simplifies prescription workflows with a user-friendly interface and easy onboarding, helping healthcare providers write and manage prescriptions efficiently. The system is Surescripts-certified, allowing it to safely check for potential drug and allergy interactions. Providers can view a patient’s medication history, helping them make informed decisions during treatment. Additionally, users can build custom templates for commonly prescribed drugs and dosages. If needed, prescriptions can also be printed for patients who prefer physical copies.

Pros

• No need for a full EHR to begin prescribing
• Simple setup and intuitive interface
• Option to support controlled substance prescriptions through an upgrade

Cons

• Expanding system integration may lead to additional costs
• Limited functionality for staff members who don’t prescribe

8. Practice Fusion 

Practice Fusion is a cloud-based electronic health record platform that combines e-prescribing, lab and imaging order management, and patient communication tools. Users can place lab and imaging orders directly online and create custom chart templates for easier documentation. The system also includes basic alerts to help identify potential drug interactions.

Pros

• Combines EHR with e-prescribing in a single platform
• User-friendly interface that allows quick navigation
• Offers around-the-clock support and access to training materials

Cons

• Some advanced features are only available with paid plans
• Billing functions come with extra charges

9. RXNT 

RXNT is a cloud-based e-prescribing platform built with a modular setup that includes key prescribing functions. It helps users keep track of medication refills and manage patient medication lists. The system provides alerts about drug interactions and allergy risks, allowing safer prescribing decisions. Users can also view basic patient medication histories and save favorite drugs along with dosage presets for quicker access. When necessary, it offers printing and faxing capabilities to send prescriptions.

Pros

• The software is straightforward and easy to use for e-prescribing tasks.
• It allows prescribing from mobile devices, enabling work from anywhere.
• Multiple billing options give users some flexibility.
• Patient records stay updated across devices without delay.

Cons

• The free version offers only a limited set of features.
• Accessing additional tools and capabilities requires purchasing upgrades.

10. AthenaOne

Athenahealth offers an e-prescribing tool as part of its larger cloud-based EHR platform. This system links directly with local e-prescribing networks, allowing healthcare providers to order medications more accurately and cut down on prescription errors. The solution aims to simplify the prescribing workflow and improve patient safety.

Pros

• Easy to learn and navigate
• Ability to customize templates
• Includes a wide range of EHR functions

Cons

• Users often face account management challenges
• Claim management can be troublesome and inefficient

11. InSync

InSync is a cloud-based EHR system that combines practice management with revenue cycle management. Healthcare providers can issue and manage prescriptions electronically through its e-prescribing feature. This function gives access to a detailed medication database, including dosages and drug interactions, which helps maintain safe medication practices. Providers also have the ability to review patients’ medication histories, allergies, and other important details that influence prescribing decisions.

Pros:

• Providers can create and adjust templates to fit their needs
• The interface is easy to navigate
• Offers various reporting tools to help analyze practice data

Cons:

• The cost may be prohibitive for some healthcare practices
• Users might face a steep learning curve when starting out

12.  75Health 

75Health enables clinicians to generate and send digital prescriptions for medications straight from the EHR system. This approach reduces mistakes common with handwritten prescriptions and helps manage patient medication records more effectively. Clinicians can review potential drug interactions to promote safer treatment options. The system complies with HIPAA standards, ensuring patient data stays secure and meets regulatory requirements.

Pros

• Includes analytics and reporting tools to support better decision-making.

Cons

• The learning curve may slow down the initial adoption and use of the system.

13. TriZetto

TriZetto’s electronic prescribing tool helps healthcare providers improve how they manage and prescribe medications. It works closely with other TriZetto healthcare systems to give doctors and pharmacists quick access to patient medication histories. With built-in clinical decision tools, the system guides healthcare professionals as they make prescription decisions, reducing the chance of errors and improving treatment outcomes. The system also makes it easier to handle prior authorizations and highlights patient-specific risks before prescriptions are finalized.

Pros:

• Immediate access to patients’ medication histories and built-in clinical guidance
• Supports digital handling of prior authorizations and customized prescription alerts
• Cloud-based setup with strong data protection and compliance features

Cons:

• High upfront cost and training requirements can be a barrier for some organizations
• May not work well with systems outside the TriZetto environment

14. PrognoCIS EHR

PrognoCIS lets healthcare providers send prescriptions, including controlled substances, directly to pharmacies through its electronic prescribing feature. This function makes it easier to handle prescriptions, reduces the chances of errors, and gives providers faster access to patient medication records. It also helps manage refills and review medication histories without switching platforms.

Pros

• Customizable templates and workflow options
• Simple, easy-to-navigate interface
• Helpful tools for managing the revenue cycle

Cons

• Takes time for new users to fully learn the system
• Fewer third-party integration options than other platforms

15. Intergy 

Intergy is a cloud-based EHR and practice management system made for ambulatory practices of various sizes. With this tool, healthcare providers can send prescriptions directly to pharmacies from within the system. The software keeps each patient’s medication list current, which helps doctors make better decisions when prescribing or changing medications. It also alerts them to possible drug interactions and allergies through a single, integrated dashboard.

Pros

• Mobile access makes it convenient for providers to document care on the go
• In-workflow PDMP (Prescription Drug Monitoring Program) checks help save time during patient visits

Cons

• Some features might take time to learn
• Certain functionalities may require buying extra add-ons separately

16. iPrescribe

iPrescribe helps healthcare professionals send prescriptions quickly and securely. Created by DrFirst, the platform works on both mobile devices and computers. It supports prescribing for both controlled and non-controlled substances, regardless of whether an EHR system is involved. Doctors can easily check a patient’s medication history, identify possible drug interactions, and access PDMP data without jumping between multiple tools. In addition, the app improves how doctors stay in touch with patients. When a prescription is sent, patients automatically receive a text alert. The platform also protects a doctor’s privacy with caller ID masking when follow-ups are needed.

Pros

• Works on mobile and desktop without needing EHR software
• Supports electronic prescribing of controlled substances (EPCS) and PDMP checks within the same workflow

Cons

• Offers fewer customization options than some EHR-connected platforms
• May require a short training period to use all features comfortably

17.  Meditech 

Meditech includes an electronic prescribing system as part of its larger electronic health record (EHR) platform. This system helps healthcare professionals manage medication orders more effectively within clinical settings. It connects with pharmacy databases and inventory systems to support accurate medication tracking and reduce prescription mistakes. The platform also includes clinical decision support, which assists in reviewing prescriptions before they’re finalized, helping to prevent errors and improve coordination across teams.

Pros

• Allows healthcare providers to access patient data securely, even from remote locations
• Improves collaboration and communication among care teams

Cons

• The interface may feel outdated compared to newer systems
• Customization options for specific clinical workflows are limited

18. PracticeSuite 

PracticeSuite offers a cloud-based electronic prescribing software that works closely with its EHR platform. It improves prescribing accuracy and speeds up the process by providing drug interaction alerts, formulary information, and electronic prior authorization. The system also handles electronic prescribing of controlled substances (EPCS), meeting all regulatory requirements. Users can access the platform from any device with internet, helping reduce medication mistakes and lessen administrative tasks.

Pros

• Accessible on any internet-enabled device
• Provides drug interaction and allergy alerts
• Supports prescribing controlled substances electronically

Cons

• New users may face a steep learning curve
• Occasionally experiences performance slowdowns

19. CareCloud

CareCloud’s electronic prescribing system is part of its larger cloud healthcare platform, helping clinicians manage their workflow and improve patient safety. It connects with Surescripts to provide instant access to medication histories, allergy information, and alerts about possible drug interactions. The system also allows healthcare providers to create and adjust order sets and treatment templates, making the prescribing process more efficient.

Pros:

• Instant access to patients’ medication histories through Surescripts
• Allergy and drug interaction alerts to reduce errors
• Ability to customize order sets and treatment templates for easier prescribing

Cons:

• Recent updates have added complexity to the prescription module, making it harder to navigate

20. AdvancedMD

AdvancedMD is a cloud-based electronic prescribing software that helps healthcare providers manage medications more efficiently. It connects with electronic health records and practice management systems, allowing users to send prescriptions electronically, review patients’ medication histories, and check formularies. Many users appreciate its low cost and user-friendly interface, but some have encountered problems with slow response times and unhelpful customer support.

Pros:

• Combines eRx with EHR functions
• Provides easy access to detailed medication histories

Cons:

• Some users experience freezing and slow performance
• Offers limited options for customization

21. ChARM Health

ChARM Health provides a cloud-based electronic prescribing (eRx) system that helps healthcare providers manage medications more effectively. It connects with over 70,000 pharmacies across the U.S., allowing prescriptions to be sent securely and quickly. The system features a detailed drug database and alerts users about potential drug interactions. It also supports Electronic Prescribing of Controlled Substances (EPCS), helping providers stay compliant with regulations. Its simple interface and ability to work alongside other healthcare tools contribute to smoother daily operations in medical practices.

Pros

• Many users find the software intuitive and easy to navigate.
• It includes integration options with labs, e-prescription services, and e-commerce platforms.

Cons

• Some users have experienced delays and challenges with customer service support.
• A few users reported problems related to the billing functions.

22. CoverMyMeds

CoverMyMeds is a cloud-based platform that helps healthcare providers and pharmacies manage the entire patient medication process more efficiently. Through its online portal, providers can handle prior authorization (PA) and hub enrollment right at the point of selecting a medication. This platform allows providers to complete, submit, and track PA requests quickly with just a few clicks. It also offers reporting tools to uncover trends and identify gaps in workflows, improving the experience for patients, providers, and pharmacies alike.

Pros

• Automates and simplifies the prior authorization process
• Provides benefit checks that verify patient coverage instantly

Cons

• Some users experience repetitive or unclear questions during the prior authorization steps

23. DoseSpot Plus+

DoseSpot Plus+ is a cloud-based e-prescribing platform that connects with EHR systems. It allows healthcare providers to send prescriptions securely, check for potential drug interactions automatically, and handle controlled substances using Electronic Prescriptions for Controlled Substances (EPCS). The platform helps healthcare professionals manage prescriptions more efficiently, improve medication safety, and meet regulatory requirements.

Pros

• Fast setup makes onboarding easier for new users
• Responsive and helpful customer support team

Cons

• Searching for patient records can be difficult and time-consuming

24. Rcopia 

Rcopia, built by DrFirst, is an e-prescribing platform that helps healthcare professionals manage medications more efficiently. It includes useful tools such as predictive analytics, electronic prior authorizations, and access to a detailed medication history. These features support more accurate prescribing and promote better patient safety. Rcopia works well with EHR systems and allows users to prescribe both standard and controlled medications. It also includes functions that track how well patients stick to their medication plans, giving providers more insight during treatment.

Pros

• Predictive analytics and clinical alerts help reduce errors
• Access to complete medication history supports better clinical decisions

Cons

• Some users have reported occasional glitches and reliability concerns
• The platform can take time to learn due to its many features

25. ScriptSure 

ScriptSure Cloud ERX helps healthcare providers send prescriptions electronically to both retail and mail-order pharmacies through the Surescripts network. Instead of flipping through physical references or separate databases, providers can quickly search for medications by brand, generic name, class, or specialty all sorted alphabetically. The system organizes prescribed medications for each patient and keeps a clear history for future reference. It also uses color-coded indicators to flag changes in dosage or discontinued prescriptions, making it easier to track patient progress. To make daily tasks more manageable, ScriptSure includes helpful toolbars that allow providers to sort prescriptions by date, drug name, or status. This setup not only simplifies medication management but also improves accuracy in prescribing.

Pros

• Custom notes and templates support more personalized patient care
• Easy access to a large, searchable drug database helps avoid errors

Cons:

• Some users may need time to get familiar with the interface
• Doesn’t always connect smoothly with certain third-party systems

26. Meditab 

Meditab makes e-prescribing easier for healthcare providers by connecting directly with pharmacies. This reduces manual tasks and lowers the chances of prescription errors. Within a patient’s chart, providers can quickly send prescriptions using just a few clicks. The system includes helpful tools like drug interaction alerts, eligibility checks, and PDMP tracking—all accessible through a clean and intuitive interface. Practices can choose between cloud-based or on-site setup, depending on their needs and preferences.

Pros

• Includes templates for specific medical specialties
• Interface is straightforward and simple to use
• Offers built-in features for checking drug interactions and patient eligibility

Cons

• Drag-and-drop features need improvement, based on user feedback
• Some users report that customer support could be more responsive

27. DigitalRx

DigitalRx helps pharmacies manage prescriptions more efficiently while improving how they interact with patients. Suitable for both small and large pharmacies, it includes tools for managing prescriptions, engaging with patients, and analyzing business performance. Many users find it easy to use and cost-effective. Its ability to support multiple locations also makes it especially useful for independent pharmacies that need to handle daily operations smoothly.

Pros:

• User-friendly interface
• Affordable pricing
• Supports multi-store operations

Cons:

• Customer support delays

28. OrderConnect

OrderConnect is an online platform for electronic prescribing and managing medications. It works smoothly with existing EHR systems but also operates independently if needed. The platform holds EPCS certification, which means it meets the required standards for prescribing controlled substances safely. It includes tools such as drug interaction and allergy alerts and access to patients’ medication records, helping healthcare providers maintain patient safety and improve their daily tasks.

Pros

• Certified for secure prescribing of controlled substances
• Provides up-to-date drug interaction and allergy alerts

Cons:

• Some users find the interface difficult to navigate

29. iMed e-Rx

iMed e-Rx is a cloud-based electronic prescribing software created by iMedWare that helps healthcare providers manage prescriptions more effectively. It includes features such as electronic prior authorization, formulary support, and adherence to EPCS regulations. The system operates across all U.S. states and uses the SureScripts network to securely transmit prescriptions. It also provides alerts for drug interactions and allergies while monitoring prescription delivery around the clock. These functions work together to improve patient safety and support medical professionals in handling their prescribing tasks efficiently.

Pros:

• Approved for e-prescribing in every U.S. state
• Meets EPCS regulatory requirements
• Includes electronic prior authorization and formulary support
• Offers checks for drug interactions, allergies, and disease considerations

Cons

• Integration options with other systems are limited

30. iCare 

iCare e-Prescribe makes the prescription process easier by allowing electronic prescribing of controlled substances tracking prescriptions as they progress, and checking for possible drug interactions. It connects directly with EHR, giving healthcare providers a single platform to manage patient information and prescriptions. The system features an intuitive interface that helps improve efficiency and supports safer medication management.

Pros

• Combines clinical, billing, and administrative functions into one platform
• Cloud-based system that updates regularly to stay current

Cons

• Pricing may be higher compared to other options on the market.

Selecting the right e-prescribing software can boost compliance, enhance patient safety, and improve how smoothly your practice runs. If you need a standalone tool or a system that connects with your existing EHR, the options listed above offer a strong starting point for safer and quicker prescribing. Take time to assess each choice according to your practice’s size, specialty, specific regulations, and how well it fits with your current technology.